Cheap Flights from John Wayne Airport to Des Moines (DSM) Find and Compare the Best Airline Deals

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2025/5
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Other Destinations from:Santa Ana

John Wayne－Detroit(Metropolitan)
USD507〜
* Fares vary in accordance to seat availability
Other Departures to: Des Moines
* Fares vary in accordance to seat availability

Santa AnaJohn Wayne AirportDes MoinesDes Moines International Airport